Hi Christopher
As an inveterate experimenter, model maker and hobbyist, you have my admiration in doing things your own way, and I wish you every success.
For someone with the necessary skills, and accurate machining ability, using modern adhesives, it may well be a suitable way forward. The strength in any accurately, well made, box type construction is immense as I'm sure you are aware, but for most people reading this forum, sticking to the construction method in the plans is the surest way to get a safe and reliable result. Basically my comments are not aimed at you, or anyone else with the necessary skills, but simply a bit of a warning to to the inexperienced.
I'm interested in the glue, I've not come across polyurethane glue before. Can any excess be easily removed when wet, like PVA? Is it waterproof once set?
Keep us posted as you go
Best Wishes
Walter